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Ventilation is an extremely important link related to the safety of mine production. Three-dimensional ventilation simulation system plays a very important role in the safety management of mine ventilation. The ventilation design of new mines, the selection of chief ventilator, and the optimization to the ventilation system of old mines are all inseparable from the accurate calculation of the ventilation network. For the network design of actual mine ventilation, it is often necessary to consider the rationality of the entire ventilation network from many aspects.